Reinforced concrete (RC) structures are exposed to aging and several degradation mechanisms, with corrosion being one of the primary threats to bridges. Corrosion is often caused by the use of deicing salts and exposure to airborne chlorides or seawater in marine environments. Climate change is influencing initiation and propagation of corrosion by altering climatic driving factors such as temperature and relative humidity. This paper investigates the effects of climate change on the life-cycle reliability of RC structures exposed to chloride-induced corrosion, with emphasis on bridges. The methodology includes the simulation of chloride diffusion and corrosion damage under climate change and probabilistic assessment of time-variant structural performance based on nonlinear static analysis. The proposed approach is applied to a RC bridge pier considering different climate change scenarios. The results show the impact of combined effects of chloride exposure and global warming on life-cycle structural reliability